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Resources and sources of evidence

Other Information for people with RRMS, their friends and family

Medically approved information about DMTs for people with RRMS

  1. Betaferon 250 microgram/ml, powder and solvent for solution for injection. Summary of Product Characteristics - Updated 03 December 2018 https://www.ema.europa.eu/en/documents/product-information/betaferon-epar-product-information_en.pdf
  2. Medicines and Healthcare Products Regulatory Agency. Dimethyl fumarate (Tecfidera): Updated advice on risk of progressive multifocal leukoencephalopathy - Updated 18 April 2016. https://www.gov.uk/drug-safety-update/dimethyl-fumarate-tecfidera-updated-advice-on-risk-of-progressive-multifocal-leukoencephalopathy
  3. Tecfidera 120mg and 240mg gastro-resistant hard capsules. Summary of Product Characteristics - Updated 18 January 2019. https://www.ema.europa.eu/en/documents/product-information/tecfidera-epar-product-information_en.pdf
  4. Copaxone 20mg/ml, solution for injection, Pre-Filled Syringe. Summary of Product Characteristics - Updated 10 Jan 2019. https://www.tevauk.com/mediafile/id/46810.pdf
  5. Aubagio 14mg film-coated tablets. Summary of Product Characteristics - Updated 27 March 2019. https://www.ema.europa.eu/en/documents/product-information/aubagio-epar-product-information_en.pdf
  6. Mavenclad 10 mg tablets. Summary of Product Characteristics - Updated 8 August 2018. https://www.ema.europa.eu/en/documents/product-information/mavenclad-epar-product-information_en.pdf
  7. OCREVUS 300 mg concentrate for solution for infusion - Updated 25 January 2018. https://www.ema.europa.eu/en/documents/overview/ocrevus-epar-summary-public_en.pdf
  8. Lemtrada 12 mg concentrate for solution for infusion. Summary of Product Characteristics - Updated 15 January 2019. https://www.ema.europa.eu/en/documents/product-information/lemtrada-epar-product-information_en.pdf
  9. European Medicines Agency. Lemtrada Annex I Summary of product characteristics - Updated 15 January 2019. https://www.ema.europa.eu/en/documents/product-information/lemtrada-epar-product-information_en.pdf
  10. Gilenya 0.25mg and 0.5mg hard capsules. Summary of Product Characteristics - Updated 9 April 2019. https://www.ema.europa.eu/en/documents/product-information/gilenya-epar-product-information_en.pdf
  11. Tysabri 300 mg concentrate for solution for infusion. Summary of Product Characteristics - Updated 31 May 2017. https://www.ema.europa.eu/en/documents/overview/tysabri-epar-summary-public_en.pdf

Medical sources for RRMS and DMTs

  1. Baker D, Marta M, Pryce G, et al, Memory B cells are major targets for effective immunotherapy in Relapsing Remitting Multiple Sclerosis. EBioMedicine. 2017; 16: 41-50.
  2. Browne P, Chandraratna D, Angood C, et al. Atlas of multiple sclerosis 2013: a growing global problem with widespread inequity. Neurology. 2014; 83:1022-1024.
  3. Dobson R, Dassan P, Roberts M, et al. UK consensus on pregnancy in multiple sclerosis: ‘Association of British Neurologists’ guidelines. Practical Neurology. 2019. 19:106-114.
  4. Eskyte I, Manzano A, Pepper G, et al. Understanding treatment decisions from the perspective of people with relapsing remitting multiple Sclerosis: A critical interpretive synthesis. Multiple Sclerosis and Related Disorders, 2019. 27: 370-377.
  5. Giovannoni G, Butzkueven H, Dhib-Jalbut S, et al. Brain health: time matters in multiple sclerosis. Multiple Sclerosis and Related disorders, 2016. 9: S5-S48.
  6. Lublin FD, Reingold SC, Cohen JA, et al. Defining the clinical course of multiple sclerosis: The 2013 revisions. Neurology, 2014. 83:278-286.
  7. Mackenzie IS, Morant SV, Bloomfield GA, et al. Incidence and prevalence of multiple sclerosis in the UK 1990–2010: a descriptive study in the General Practice Research Database. Journal Neurology Neurosurgery Psychiatry 2014. 85:76-84.
  8. National Institute for Care and Health Excellence (NICE). Managing Multiple Sclerosis NICE Pathway - Updated 29 January 2019. http://pathways.nice.org.uk/pathways/multiple-sclerosis
  9. National Institute for Care and Health Excellence (NICE). Multiple Sclerosis Quality Standard - Updated 14 January 2016. nice.org.uk/guidance/qs108 https://www.nice.org.uk/guidance/qs108/resources/multiple-sclerosis-pdf-75545244362437
  10. National Institute for Care and Health Excellence (NICE). Disease-modifying therapies for multiple sclerosis. NICE Pathway - Updated 29 January 2019 https://pathways.nice.org.uk/pathways/multiple-sclerosis/disease-modifying-therapies-for-multiple-sclerosis
  11. NHS England. Treatment Algorithm for Multiple Sclerosis Disease-Modifying Therapies. NHS England Reference: 170079ALG. Gateway reference: 07603 - Updated 8 March 2019. https://www.england.nhs.uk/commissioning/wp-content/uploads/sites/12/2019/03/Treatment-Algorithm-for-Multiple-Sclerosis-Disease-Modifying-Therapies-08-03-2019-1.pdf
  12. Scolding N, Barnes D, Cader S, et al. Association of British Neurologists: Revised (2015) guidelines for prescribing disease-modifying treatments in multiple sclerosis. Practical Neurology, 2015. 15:273-279.
  13. Thompson AJ, Banwell BL, Barkhof F, et al. Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria. The Lancet Neurology, 2018. 17:162-173.
  14. Rae-Grant, A., Day, G.S., Marrie, R.A., et al, 2018. Comprehensive systematic review summary: Disease-modifying therapies for adults with multiple sclerosis: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology. Neurology, 90(17), pp.789-800.
  15. Lucchetta R, Tonin FS, Borba HHL, et al. Disease-Modifying Therapies for Relapsing-Remitting Multiple Sclerosis: A Network Meta-Analysis. 2018. CNS Drugs. 32:813-826
  16. Webb EJ, Meads D, Eskyte I, et al. A Systematic Review of Discrete-Choice Experiments and Conjoint Analysis Studies in People with Multiple Sclerosis. The Patient-Patient-Centered Outcomes Research. 2018.

Patient decision aid sources

  1. Bekker H, Thornton JG, Airey CM, et al. Informed decision making: an annotated bibliography and systematic review. UK: Health Technology Assessment Number. 1999. 3. NHS R&D.
  2. Bekker HL, Winterbottom A, Gavaruzzi T, et al. The dialysis decision aid booklet: making the right choices for you - Updated Sept 2017. Kidney Research UK: Peterborough, UK.
  3. Elwyn G, O’Connor A, Stacey D, et al. International Patient Decision Aids Standards (IPDAS) Collaboration. Developing a quality criteria framework for patient decision aids: online international Delphi consensus process. BMJ. 2006. 26:417.
  4. Sepucha K, Abhyankar P, Hoffman A, et al. Standards for UNiversal reporting of patient Decision Aid Evaluation studies: the development of SUNDAE Checklist. BMJ Qual Saf 2018; 27:380-388.
  5. O’Connor, Stacey, Jacobsen. Ottawa Personal Decision Guide. (2015). Ottawa Hospital Research Institute & University of Ottawa, Canada.
  6. Ferron Parayre A, Labrecque M, Rousseau M, et al. Validation of SURE, a four-item clinical checklist for detecting decisional conflict in patients. Med. Dec. Mak. 2014. 34:54-62.
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